Мутации заказывали?

ЦитатаУченые из США провели исследование и выявили новую опасность COVID-19. Самая распространенная мутация в геноме SARS-CoV-2 повышает шанс вируса проникать в клетки организма человека от 2,5 до 8 раз. Именно эта мутация характерна для более чем половины изученных штаммов вируса. Новый изолят SARS-CoV-2 несет точечную мутацию в белке D614G и уже быстро превзошел другие по распространенности.

ЦитатаGiven the global efforts underway to develop a COVID-19 vaccine, we also sought to understand the impact of the Spike variant on immune responses. According to the World Health Organization, there are presently 126 COVID-19 vaccine candidates in preclinical development and 10 vaccine candidates in patient-enrolling clinical trials (https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines, accessed June 10th, 2020). Despite the tremendous diversity of vaccine formulations and delivery methods, many of the them utilize Spike sequences (RNA or DNA) or peptides and were developed prior to the emergence of the G614 variant. Using epitope prediction for common HLA alleles¹⁶, we found that the G614 variant can alter predicted MHC binding (Supplementary Fig. 4). For example, the predicted binding for one high-affinity epitope decreased by nearly 4-fold (58nM for D614 versus 221nM for G614 with HLA-A*02:01). Although full-length Spike protein likely can produce many immunogenic peptides, several vaccines use only portions of Spike^6,7 and thus it may be better to adapt vaccine efforts to the D614 variant given its global spread.