Цитата: Doctor_D от 12.05.2020 11:27:22В целом, у меня складывается мнение, что иммунитет достаточно нестойкий, особенно, у перенесших болезнь в легкой форме.
вполне возможно... вот что еще пишут по этому поводу:
leolion-1.livejournal.com/1577617.html?thread=32270737
#t32270737SARS-CoV-2-specific NAbs were detected in patients from day 10-15 after the onset of the disease and remained thereafter. The titers of NAb among these patients correlated with the spike-binding antibodies targeting S1, RBD, and S2 regions. The titers of NAbs were variable in different patients.
Elderly and middle-age patients had significantly higher plasma NAb titers (P < 0.0001) and spike-binding antibodies (P=0.0003)
than young patients. Notably, among these patients, there were ten patients whose NAb titers were under the detectable level of our assay (ID50: < 40); while in contrast, two patients, showed very high titers of NAb, with ID50 :15989 and 21567 respectively. The NAb titers were positive correlated with plasma CRP levels but negative correlated with the lymphocyte counts of patients at the time of admission, indicating an association between humoral response and cellular immune response. Interpretation
The variations of SARS-CoV-2 specific NAbs in recovered COVID-19 patients may raise the concern about the role of NAbs on disease progression.
https://www.medrxiv.org/content/10.1101/2020.03.30.20047365v2кстати, пишут что против кошачьего коронавируса эффективной вакцины нет, и иммунитет практически не образуется:
leolion-1.livejournal.com/1577617.html?thread=32280977
#t32280977ADE in coronavirus infectionsThe feline infectious peritonitis virus (FIPV) is a highly virulent variant of feline coronavirus, an alphacoronavirus that is highly prevalent in both wild and domestic cats.
Immunisation against FIPV paradoxically increases the disease severity.
In vitro infection of macrophages by FIPV can be enhanced by non-neutralising monoclonal antibodies against the spike viral protein, and this phenomenon may occur even with highly diluted neutralising antibodies.
In addition, as many as
50% of cats passively immunised with anti-FIPV antibodies develop peritonitis when challenged with the same FIPV serotype. An attenuated virus vaccine is currently available in several countries for intranasal delivery, but its use is still deemed controversial by some experts, both in terms of safety and efficacy.
ADE has been reported also for a human coronavirus infection, severe acute respiratory syndrome (SARS-CoV).
Antibodies elicited by a SARS-CoV vaccine enhanced infection of B cell lines in spite of protective responses in the hamster model... These results were confirmed using a HL-CZ human promonocyte cell line. Here,
infection with SARS-CoV was neutralised by concentrated antisera against the spike protein, but higher dilutions not only failed to prevent infection, but even facilitated it and induced higher levels of apoptosis. Conversely, anti-nucleocapsid antibodies did not exert any effect − they neither neutralised infection nor caused viral ADE.
Cross-reactivity of antibodies against the spike protein of SARS-CoV-2 and SARS-CoV is common, and some preliminary data claim that they seem to be rarely cross-neutralising...
https://smw.ch/article/doi/smw.2020.20249